A native of Philadelphia, Bloch was married for 58 years to Richard Bloch, co-founder of the tax filing company H&R Block. After Richard Bloch survived a diagnosis of lung cancer that he was told was likely to be terminal, he retired in the early 1980s and began focusing his efforts on cancer treatment and support services. Together, they founded the R.A. Bloch Cancer Foundation, which later became the Richard & Annette Bloch Family Foundation, providing assistance to many people diagnosed with cancer. She donated millions to cancer research and DAP Health, and was active with the Palm Springs Art Museum and other causes and died Saturday July 17 2021 in Kansas at the age of 94 after a battle with cancer. Bloch was predeceased by her husband, Richard, in 2004. She is survived by her companion of 17 years, Andrei Muresan; three daughters, Barbara Huson (Lee), Nancy Linsley (Michael), and Linda Lyon (Mike); 10 grandchildren and 14 great-grandchildren.