George Shapiro was born in the Bronx and graduated from New York University with a degree in advertising and marketing. He took a job in the mailroom at the William Morris Agency in New York where he advanced rapidly within the company and soon became an agent. He is responsible for packaging hit television programs such as "THE STEVE ALLEN SHOW," "THE SMOTHERS BROTHERS COMEDY HOUR," "THAT GIRL" starring Marlo Thomas, and "GOMER PYLE," starring his client, Jim Nabors. Shapiro also packaged specials for Dick Van Dyke, Mary Tyler Moore and Carol Channing. Shapiro eventually left the William Morris Agency to become a personal manager and producer. He managed Andy Kaufman, executive producing the comedian's special for Showtime and for NBC, he Executive Produced "A COMEDY SALUTE TO ANDY KAUFMAN." He executive produced the Universal film "MAN ON THE MOON" starring Jim Carrey in the role of Andy Kaufman. Danny De Vito co-starred portraying George Shapiro, with two-time Academy Award winner Milos Forman directing. George Shapiro's uncle is Carl Reiner, his aunt is Estelle Reiner, and his cousins are Rob and Lucas Reiner.